The prostate is normally about 3 cm long (slightly more than 1 inch) and lies at the neck of the bladder and in front of the rectum.

The prostate surrounds the urethra, which is a tubular structure that carries sperm and urine out of the penis.

It produces a thin, milky fluid that is added to the sperm at the time of ejaculation.

Older men often have an enlarged prostate, which is a noncancerous condition called benign prostatic hypertrophy (BPH) that causes urinary symptoms.
Cancer occurs when normal cells undergo a transformation in which they grow and multiply without normal controls.

As the cells multiply, they form a mass called a tumor.

Tumors are cancerous only if they are malignant. This means that they invade neighboring tissues because of their uncontrolled growth.

They may also travel to remote organs via the bloodstream.

This process of invading and spreading to other organs is called metastasis.

Tumors overwhelm surrounding tissues by invading their space and taking the oxygen and nutrients they need to survive and function.
Almost all prostate cancers arise from the secretory glandular cells in the prostate. Cancer arising from a glandular cell is known as adenocarcinoma. Therefore, almost all prostatic cancers are prostatic adenocarcinomas.
In the United States, cancer of the prostate is a common malignant cancer in men, second only to lung cancer. About 200,000 new cases are diagnosed each year, and about 30,000 men die of the disease each year.

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system

Prostate Cancer Symptoms

Most men with prostate cancer have no symptoms. This is particularly true of early prostate cancer.

• Most prostate cancers are discovered incidentally when a digital rectal exam is performed.
• A digital rectal exam is part of a thorough regular health examination. Digital refers to finger.
• During the digital rectal exam, the examiner inserts a gloved and lubricated finger in the rectum to feel the prostate for abnormalities.

Symptoms usually appear when the tumor causes some degree of urinary blockage at the bladder neck or the urethra.

• The usual symptoms include difficulty in starting and stopping the urinary stream, increase in frequency of urination, and painwhile urinating.
• The urinary stream may be diminished (urinary retention), or it may simply dribble out.
• Even after urination, there is a sense of bladder fullness because the bladder has not been fully emptied.

Less common symptoms are blood in the urine (hematuria), painful ejaculation, orimpotence (inability to have an erection).

• These 3 symptoms are uncommon in early stages of the disease. They usually occur when the cancer is advanced.
• As the cancer advances to cause a greater blockage, bladder function may deteriorate further.
• Men with such advanced cancers sometimes experience recurring urinary tractinfections.

Despite these symptoms, many men do not seek medical care until the cancer has spread. Symptoms of metastatic disease include fatigue, malaise, and weight loss. Spread to the bones causes deep bone pain, especially in the hips and back, and bone fractures from weakening of the bone.

Prostate Cancer Treatment Options:

Prostate Seed Implant – Minimally invasive surgery lasts 1-2 hours with a possible overnight stay; most return to normal activities in a few days.

Salvage Chemotherapy – Chemotherapy is administered orally, or by a computerized pump, or by frequent injections at a doctor’s office.

Minimally Invasive Surgery – Cryosurgery takes about 2 hours with a possible overnight admission.

Shrinking the Prostate – Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection.

Radiation Treatment – Radiation therapy generally requires 5 treatments per week over 6-8 weeks.

Prostate Removal – Length of prostatectomy surgeries, recovery times, and hospital stays vary according to specific prostatectomy procedure.

Monitoring and Care – Expectant therapy includes regular visits to a doctor for prostate specific antigen (PSA) tests and digital rectal exams.

Heart muscle gets its blood supply from arteries that start in the aorta and run on the surface of the heart, known as the coronary arteries. The right coronary artery supplies the right ventricle of the heart and the inferior (lower) portion of the left ventricle. The left anterior descending coronary artery supplies the majority of the left ventricle, while the circumflex artery supplies the back of the left ventricle.

Heart Attack Causes

Over time, cholesterol buildup can occur in these blood vessels in the form of plaque. This narrows the artery and can restrict the amount of blood that can flow through it. If the artery becomes too narrow, it cannot supply enough blood to the heart muscle when it becomes stressed. Just like arm muscles that begin to hurt if you lift too much, or legs that ache when you run too fast; the heart muscle will ache if it doesn’t get adequate blood supply. This ache is called angina.

If the plaque ruptures, a small blood clot can form within the blood vessel and acutely block the blood flow. When that part of the heart loses its blood supply completely, the muscle dies. This is called a heart attack, or an MI – a myocardial infarction (myo=muscle +cardial=heart; infarction=death due to lack of oxygen).

Heart Attack Symptoms

Classic symptoms of a heart attack may include:

• chest pain associated with shortness of breath,
• profuse sweating, and
• nausea.

The chest pain may be described as tightness, fullness, a pressure, or an ache.

Unfortunately, many people do not have these classic signs. Other presentations of heart attack may include:

• indigestion,
• jaw ache,
• pain only in the shoulders or arms,
• shortness of breath, or
• nausea and vomiting.

This list is not complete, since many times people can experience a heart attack with minimal symptoms. In women and the elderly, heart attack symptoms can be atypical and sometimes so vague as to be easily missed. The only complaint may be extreme weakness or fatigue.

Cancer gives you no symptoms or signs that exclusively indicate the disease. Every complaint for cancer can explain a harmless condition as well. If you have symptoms, however, you should see a doctor for further evaluation. Some common symptoms are as follows:

Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all human deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.

Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers are usually affected by complex interactions between carcinogens and the host’s genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.

Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.

Diagnosis usually requires the histologic examination of a tissue biopsy specimen by a pathologist, although the initial indication of malignancy can be symptoms or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments.