The cervix is the name for the lowest part of the uterus. The uterus is an organ that only women have, and it is where a baby grows and develops when a woman is pregnant. During pregnancy, the uterus has an enormous increase in size. When a woman is not pregnant, the uterus is a small, pear-shaped organ that sits between a woman’s rectum and her bladder. The cervix connects the uterus with the birth canal (the vagina). The cervix can both be visualized and sampled by your doctor during a routine pelvic examination in his or her office.

The narrow neck of the uterus is called the cervix. This is where cervical cancer may develop

What is cervical cancer?

Cervical cancer develops when cells in the cervix begin to grow out of control and can then invade nearby tissues or spread throughout the body. Large collections of cells that grow abnormally are called tumors. Some tumors are not cancer, because they cannot spread or threaten someone’s life. These are called benign tumors. The tumors that can spread throughout the body or invade nearby tissues are considered cancer and are called malignant tumors. Usually, cervix cancer is very slow growing, although in certain circumstances it can grow and spread quickly.

Cancers are characterized by the cells that they originally form from. The most common type of cervical cancer is called squamous cell carcinoma; it comes from cells that lie on the surface of the cervix known as squamous cells. Squamous cell cervical cancer compromises about 80% of all cervical cancers. The second most common form is adenocarcinoma; it comes from cells that make up glands in the cervix. The percentage of cervical cancers that are adenocarcinomas has risen since the 1970s, although no one knows exactly why. About 3% to 5% of cervical cancers have characteristics of both squamous and adenocarcinomas and are called adenosquamous carcinomas. There are a few other very rare types like small cell and neuroendocrine carcinoma that are so infrequent that they will not be discussed further here.

Cervical cancer symptoms?

Abnormal cervical cell changes rarely cause symptoms. But you may have symptoms if those cell changes grow into cervical cancer. Symptoms of cervical cancer may include:

Bleeding from the vagina that is not normal, or a change in your menstrual cycle that you can’t explain.
Bleeding when something comes in contact with your cervix, such as during sex or when you put in a diaphragm.
Pain during sex.
Vaginal discharge that is tinged with blood.

Cervical cancer treatment options?

Cervical cancer that is caught early can usually be cured. If the cancer is caught very early, you still may be able to have children after treatment.

The treatment for most stages of cervical cancer removes the cancer and makes you unable to have children. These treatments include:

A hysterectomy and removal of pelvic lymph nodes with or without removal of both ovaries and fallopian tubes. Radiation therapy. Chemotherapy.

On June 15, 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and cisplatin for women with late-stage (IVB) cervical cancer treatment. Combination treatment has significant risk of neutropenia, anemia, and thrombocytopenia side effects. Hycamtin is manufactured by GlaxoSmithKline

The prostate is normally about 3 cm long (slightly more than 1 inch) and lies at the neck of the bladder and in front of the rectum.

The prostate surrounds the urethra, which is a tubular structure that carries sperm and urine out of the penis.

It produces a thin, milky fluid that is added to the sperm at the time of ejaculation.

Older men often have an enlarged prostate, which is a noncancerous condition called benign prostatic hypertrophy (BPH) that causes urinary symptoms.
Cancer occurs when normal cells undergo a transformation in which they grow and multiply without normal controls.

As the cells multiply, they form a mass called a tumor.

Tumors are cancerous only if they are malignant. This means that they invade neighboring tissues because of their uncontrolled growth.

They may also travel to remote organs via the bloodstream.

This process of invading and spreading to other organs is called metastasis.

Tumors overwhelm surrounding tissues by invading their space and taking the oxygen and nutrients they need to survive and function.
Almost all prostate cancers arise from the secretory glandular cells in the prostate. Cancer arising from a glandular cell is known as adenocarcinoma. Therefore, almost all prostatic cancers are prostatic adenocarcinomas.
In the United States, cancer of the prostate is a common malignant cancer in men, second only to lung cancer. About 200,000 new cases are diagnosed each year, and about 30,000 men die of the disease each year.

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system

Prostate Cancer Symptoms

Most men with prostate cancer have no symptoms. This is particularly true of early prostate cancer.

• Most prostate cancers are discovered incidentally when a digital rectal exam is performed.
• A digital rectal exam is part of a thorough regular health examination. Digital refers to finger.
• During the digital rectal exam, the examiner inserts a gloved and lubricated finger in the rectum to feel the prostate for abnormalities.

Symptoms usually appear when the tumor causes some degree of urinary blockage at the bladder neck or the urethra.

• The usual symptoms include difficulty in starting and stopping the urinary stream, increase in frequency of urination, and painwhile urinating.
• The urinary stream may be diminished (urinary retention), or it may simply dribble out.
• Even after urination, there is a sense of bladder fullness because the bladder has not been fully emptied.

Less common symptoms are blood in the urine (hematuria), painful ejaculation, orimpotence (inability to have an erection).

• These 3 symptoms are uncommon in early stages of the disease. They usually occur when the cancer is advanced.
• As the cancer advances to cause a greater blockage, bladder function may deteriorate further.
• Men with such advanced cancers sometimes experience recurring urinary tractinfections.

Despite these symptoms, many men do not seek medical care until the cancer has spread. Symptoms of metastatic disease include fatigue, malaise, and weight loss. Spread to the bones causes deep bone pain, especially in the hips and back, and bone fractures from weakening of the bone.

Prostate Cancer Treatment Options:

Prostate Seed Implant – Minimally invasive surgery lasts 1-2 hours with a possible overnight stay; most return to normal activities in a few days.

Salvage Chemotherapy – Chemotherapy is administered orally, or by a computerized pump, or by frequent injections at a doctor’s office.

Minimally Invasive Surgery – Cryosurgery takes about 2 hours with a possible overnight admission.

Shrinking the Prostate – Surgical castration patients return home the day of the surgery. Treatment is given orally or by injection.

Radiation Treatment – Radiation therapy generally requires 5 treatments per week over 6-8 weeks.

Prostate Removal – Length of prostatectomy surgeries, recovery times, and hospital stays vary according to specific prostatectomy procedure.

Monitoring and Care – Expectant therapy includes regular visits to a doctor for prostate specific antigen (PSA) tests and digital rectal exams.

When a heart attack strikes, the key thing to remember is that time equals muscle. The longer the delay in seeking medical care, the more heart muscle will be damaged. There is a window of opportunity to restore blood supply to the heart muscle by unblocking the affected heart artery. Treatments must be done in a hospital and include administration of clot-busting drugs to dissolve the clot at the site of the ruptured plaque and heart catheterization and angioplasty (in which the blood vessel is opened by balloon, often with adjunctive placement of a stent), or both.

Emergency Medical Treatment

Hospitals have established treatment plans to minimize the time to diagnose and treat people with heart attack. National guidelines suggest that an electrocardiogram (EKG) be done within 10 minutes of the patient’s arrival in the ER.

Many things will occur at the same time as the EKG being completed. The doctor will take a history and complete a physical exam while the nurses start an intravenous line, place heart monitor lines on the chest, and administer oxygen.

Medications are used to try to restore blood supply to the heart muscle. If it wasn’t taken prior to arrival in the ER, aspirin will be used for its anti-platelet action. Nitroglycerin will be used to dilate blood vessels. Heparin or enoxaparin (Lovenox) will be used to thin the blood. Morphine can also be used for pain control.

There are two options (depending on the resources at the hospital) if the EKG shows an acute heart attack (myocardial infarction), and if there are no contraindications.

Heart catheterization

The favored treatment is heart catheterization. Tubes are threaded through the femoral artery in the groin or through the brachial artery in the elbow, into the coronary arteries, and the area of blockage is identified.

Angioplasty

Angioplasty (angio= artery + plasty=repair) is then considered if possible. A balloon is placed at the blockage site and as it opens, it squashes the plaque into the blood vessel wall. Afterwards, a stent or a mesh cage is placed across the angioplasty site to keep it from closing down. Guidelines recommend that the time from the time the patient presents to the hospital to having the blood vessel open be less than 90 minutes.

Not all hospitals have the capabilities of doing heart catheterizations 24 hours a day, and may transfer the patient with an acute heart attack to a hospital that has that technology available. If the transfer time will delay angioplasty treatment beyond the 90 minute window recommendation, clot-busting drugs may be considered to dissolve the blood clot that has obstructed the coronary artery. Tissue plasminogen activator (TPA or TNK) can be used intravenously. After TPA infusion, the patient may still be transferred for heart catheterization and further care.

If the EKG is normal but the history is suggestive of an heart attack or angina, the evaluation will continue with the blood tests described above. However, the patient will likely be treated as if the heart attack was happening with aspirin, oxygen, nitroglycerin and blood thinning medications until the presence of heart damage is proven not to be present. The treatment presumes heart disease until proven otherwise.

Heart Attack Complications

When a heart attack occurs, part of the heart muscle dies and is ultimately replaced with scar tissue. This leaves the heart weaker and less able to meet the needs of the body. This will lead to exercise intolerance including early fatigue or shortness of breath on exertion. The amount of disability is dependent on the amount of muscle pumping function lost.

Muscle that loses its blood supply becomes electrically irritable. This may cause a short circuit of the electrical conduction system of the heart. This may cause ventricular fibrillation, a situation where the ventricles do not beat in a coordinated function. Instead, they jiggle like a bowl of Jello and cannot pump blood to the body. Sudden death occurs. Patients are kept in the ER or admitted to the hospital while assessing chest pain to monitor their heart rhythm and hopefully prevent sudden death from acute heart attack or unstable angina which may result in ventricular fibrillation.

If this rhythm occurs while monitored in the hospital, it can be rapidly treated with no adverse sequelae.

Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all human deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.

Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers are usually affected by complex interactions between carcinogens and the host’s genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.

Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.

Diagnosis usually requires the histologic examination of a tissue biopsy specimen by a pathologist, although the initial indication of malignancy can be symptoms or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments.